Leaky Gut Syndrome


It has been said that Leaky Gut Syndrome affects millions of people worldwide. Leaky Gut Syndrome is a chronic debilitating condition that often goes undiagnosed by the mainstream medical profession, as many doctors do not provide testing for leaky gut (increased intestinal permeability) or acknowledge that the condition exists. Many people are not even aware that they are suffering from a 'leaky gut'.

Dr James A Ferrel MD claims "The Leaky Gut Syndrome may be the cause of many 'etiology unknown' illness. LGS may also explain many of the symptoms patients have that confound and confuse many physicians. In my opinion Leaky Gut Syndrome is grossly under considered as a 'mainstream' medicine diagnosis." (Dr Ferrel, www.lifedynamix.com)

The symptoms of Leaky Gut Syndrome are many and varied and include: abdominal pain, heartburn, insomnia, bloating, anxiety, gluten intolerance, malnutrition, muscle cramps and pains, poor exercise tolerance, food allergies.

Leaky Gut Syndrome has also been linked with many conditions, such as: Celiac Disease, Multiple Sclerosis, Fibromyalgia, Autism, Chronic Fatigue Syndrome, Irritable Bowel Syndrome, Eczema, Dermatitis, Ulcerative Colitis.

This website is a resource for all those who suffer from Leaky Gut Syndrome and also for those who think that they may have the condition or those that would simply like to know more about it.

You can find information on: causes of Leaky Gut Syndrome , symptoms, testing for leaky gut, treatments that can help for instance nutrition can make a dramatic difference. There are various articles by medical professionals, alternative practitioners (such as Dr Sharma and Dr Gilbere) and others who have had experience either of suffering from Leaky Gut Syndrome or helping others with the condition. As well as information on testing for Leaky Gut Syndrome you can also find reviews of common tests for symptoms associated with Leaky Gut Syndrome and other digestive disorders and illnesses, and a range of vitamins and supplements for those suffering from digestive disorders and other health issues.

My favorite online supplement store is Iherb in the U.S. because of their fantastic range of products, incredibly inexpensive prices and shipping, fast delivery and wonderful customer service. This is where I buy all my supplements from, even though I live in the UK! (which is testament to how good they are because even with import duty and VAT I'd still rather shop from there). First time buyers at Iherb can get a $5 discount off their first order by using the code DAW513 at the checkout in the promo code box.

About Leaky Gut

The official definition of Leaky Gut Syndrome is an increase in permeability of the intestinal mucosa to luminal macromolecules, antigens, and toxins associated with inflammatory degenerative and/ or atrophic mucosa or lining.

Put more simply, large spaces develop between the cells of the gut wall allowing bacteria, toxins and food to leak into the bloodstream.

70% of our immune system is located around the digestive system.[1] In a normal healthy person the small intestine behaves like a selective sieve allowing only the breakdown products of digestion into the bloodstream. [2] Nutrients and well digested fats, proteins and starches are readily able to enter into the bloodstream whilst large molecules, microbes and toxins are kept out. [3]

In the intestinal tract, villi (finger like projections off the lining the intestinal tract with hair like cell membrane extensions called microvilli), serve as a point of absorption of nutrients. Nutrients such as glucose, amino acids or electrolytes are carried through the microvilli into the cells of the villus via active transport (carrier molecules take the nutrients across the cell membrane).

Leaky Gut Syndrome causes the intestinal lining to become inflamed and the microvilli become damaged or altered. The damaged microvilli cannot then produce the necessary enzymes and secretions that are essential for a healthy digestion and the absorption of nutrients. [4]

In between cells reside desmosomes. These adhere adjacent cells together to form a strong, sturdy structure, which prevents large molecules from passing through. When an area becomes inflamed this weakens the structure of the desmosomes and larger molecules can escape through. This provokes the immune system to produce antibodies (a protein utilised by the immune system to locate and attack foreign objects) to fight off the molecules, as they are perceived as antigens (substances capable of triggering the production of antibodies).

A healthy individual would have a strong enough immune system to control the leakage of toxic substances but as it becomes over loaded the toxins leak into the liver resulting in an overworked overburdened liver. [5]

The Liver

The liver is the largest gland in the body and plays a really important part in detoxification as well as having many other functions including: producing bile, containing bile acids, which aid digestion, filtering out toxins, such as drugs, alcohol and environmental toxins, storing glucose as glycogen, then breaking it down about 4 hours after a meal to be converted to glucose to regulate blood sugar levels, converting ammonia to urea and removing damaged red blood cells.

Leaky Gut completely overworks the liver because it floods it with additional toxins diminishing the liver's ability to neutralize chemical substances. When it cannot cope with the level of toxins the liver expels them back into the bloodstream. The circulatory system then pushes the toxins into the connective tissues and muscles where the body stores them to prevent major organ damage. The liver doesn't get the time to go back and rid the body of the toxins.

As the intestinal lining becomes more and more damaged substances larger than particle size such as disease causing bacteria and fungus, potentially toxic molecules and undigested food particles pass through the weakened cell membranes. These enter the bloodstream, triggering antibodies and cytokines (protein molecules released by the immune system to cause a reaction in other cells) to fight the antigens. The cytokines alert the lymphocytes (white blood cells) to fight the particles that have escaped through the intestinal lining. Toxic oxidants are produced as a result causing allergic reactions and more inflammation throughout the body.

The digestive tract is normally coated with a mucus layer, which keeps out foreign substances. Leaky Gut Syndrome develops as the mucus layer is weakened and the bacteria, which usually resides in the intestine starts to inhabit other parts of the body as well (bacterial translocation), due to the intestinal permeability.

So put very simply your intestine develops leakages allowing substances that would normally be digested to enter the bloodstream. These toxins are passed onto the liver to deal with but it cannot cope with the overwhelming toxins and stores them in the body tissues to come back to later on. The liver is too overworked to go back to the toxins and as the intestinal lining gets consistently weaker more and more toxins and undigested food enter into the bloodstream. The immune system sends out antibodies to fight these foreign substances and in doing that toxic oxidants are produced which attack the body tissues causing allergic reactions and pain and inflammation throughout the body.

[1] Spaeth G, Berg RD, Specian RD, Deitch EA, August 1990, "Food Without Fiber promotes bacterial translocation from the gut" Surgery 108 (2) pp 204-47
[2] Sharma R, 2005, Leaky Gut Syndrome, article.
[3] Lipski E Leaky Gut Syndrome, 1998, "What to do about a health threat that can cause arthritis, allergies and a host of other illnesses" p10 Keats
[4] Gilbere G, 2001, I Was Poisoned By My Body...I Have A Gut Feeling You Could Be, Too, p10, Lucky Press.
[5] Gilbere G, 2001, I Was Poisoned By My Body...I Have A Gut Feeling You Could Be, Too, p11, Lucky Press.

 Causes of Leaky Gut Syndrome

There are many factors that contribute to the development of a leaky gut or which seem to go hand in hand with the condition. Some of the main causes of Leaky Gut Syndrome are featured on this website, but there are always other factors to consider. If you think you might have Leaky Gut Syndrome you can find information on the testing pages about how to get tested for the condition. Click on the links above to go to the relevant pages where you can find more information about each of the causes.

Symptoms Of Leaky Gut

Below you can find a list of symptoms associated with Leaky Gut Syndrome:

Abdominal pain (chronic)
Excessive flatulence
Anaphylactoid reactions
Shortness of breath
Fevers of unknown origin
Gluten intolerance (celiac disease)
Muscle cramps
Multiple chemical sensitivities
Muscle pain
Myofascial pain
Mood swings
Poor exercise tolerance
Poor immunity

Poor memory
Recurrent bladder infections
Recurrent vaginal infections
Recurrent skin rashes
Brittle nails
Hair loss
Swollen lympth glands
Food allergies
Liver dysfunction
Brain fatigue
Abdominal spasms
Anal irritation
Constant hunger pains
Depleted appetite
Chronic fatigue  


Conditions linked with LGS

Below you can find a list of conditions that have been linked with Leaky Gut Syndrome:

Celiac disease
Multiple Sclerosis
Chronic Fatigue Syndrome
Irritable Bowel Syndrome
Ulcerative Colitis
Chronic hepatitis
Cystic Fibrosis
Multiple Chemical Sensitivities
Accelerated Aging

Colon cancer
Crohn's disease
Food allergies
Pancreatic dysfunction
Anyklosing spondylitis
Inflammatory bowel disease
Liver dysfunction


Testing For Leaky Gut

Below are some of the options available to you if you would like to test for Leaky Gut Syndrome and related conditions or problems. Additionally, some test providers have supplied details of the testing that they offer for Leaky Gut, such as: The Diagnostic Clinic, IWDL and Biolab.

PolyethelyneGlycol (PEG) Test

This is the most common form of testing for leaky gut. The person is given a solution containing mannitol and lactulose and collects their urine for six hours to be tested. Lactulose (a disacharride) and Mannitol (a monosaccharide) are two water soluble, non- metabolised sugar molecules. Mannitol is easily absorbed, penetrating cells, whilst Lactulose has larger molecules and is only partially absorbed. If the levels of mannitol and lactulose in the collected urine sample are high it is indicative of Leaky Gut Syndrome. Low levels of both molecules indicate malabsorption of nutrients. High levels of lactulose and low levels of Mannitol indicate that the person has healthy digestion.

Digestive Stool Analysis

This involves testing of a stool sample for: digestive function, how well fats, proteins, carbohydrates and other nutrients are absorbed in the colon, presence of candida or other bacterial infections, dysbiosis (imbalance in intestinal bacteria), parasitic infection and other indicators of digestive dysfunction.

Candida Testing

The tests most commonly used involved testing the blood for high levels of antibodies such as IgG, IgA and IgM, which could indicate Candidiasis.

Allergy/ Intolerance/ Sensitivity Testing

Your doctor can refer you for allergy testing. The methods below are the most common forms of testing that are offered:

A skin prick or scratch test, where a drop of fluid containing the allergen is placed on the surface of the skin and then the skin is pricked to push the allergen just under the skin surface (usually the forearm, back or upper arm). If the person is has an allergy the skin will swell, become itchy and red and a white swelling called a wheal develops, which fades after several hours.

Also the allergen can be injected underneath the skin surface and monitored for a reaction.

A blood RAST (radioallergosorbent) test that measures the amount of IgE in the blood when exposed to various allergens is also used for true allergies.

Patch tests are used to diagnose delayed allergic reactions that cause skin rashes, such as dermatitis. Traces of the allergen are taped to the skin for 48 hours and a dermatologist measures reactions. Tests can be performed for respiratory or food allergies.

Food Allergy/ Sensitivity Testing

If you choose to order your own food allergy testing instead of going via the doctor there are places that offer true allergy testing, for instance YORKTEST offer an allergy test against 36 of the most common food and inhalant allergens, which requires a blood sample taken by a doctor or nurse.

Food allergies can be tested for by elimination diets, where the foods suspected of causing an allergic reaction are eliminated from the diet for several months. This needs to be undertaken with the assistance of a qualified health practitioner.

There are blood tests available to test for food intolerances, which test a pin-prick blood sample against a number of foods for various antibody reactions, depending on where you get the test done. York Test are the most well known and offer testing for up to 113 different food types.

Live Blood Cell Analysis

Live Blood Cell Analysis involves the patient giving a pin-prick blood sample, which is placed on a microscopic slide, underneath a glass coverslip, to prevent it from drying up. Following this the slide is viewed by the practitioner through a dark field microscope (at high magnification), which then transfers the image to a television monitor, for the patient to view simultaneously.

The practitioner then assesses from how the blood appears, the patients state of health. It is said that the movement of the red and white blood cells can be seen along with: the presence of pathogens and free radicals, immune system function, digestive function, liver or pancreatic problems, oxidative stress, presence of bacteria, parasites and fungus, malnutrition, stress to the system, vitamin and mineral deficiencies, along with other indicators of poor health and disease. It is not a method of diagnosis but a screening process indicating where health problems may lie.

Amino Acid Analysis

Amino Acids combine to form protein required by the body. They repair tissue, produce antibodies to prevent infection, carry oxygen throughout the body, aid the production of hormones such as insulin, amongst other important functions. There are eight 'essential' amino acids that the body cannot manufacture and which must be gleaned from dietary sources and the other 'non -essential' amino acids can be produced by the body. A low protein diet and poor health can cause deficiencies in amino acids. The amino acid test calculates amino acid levels in a 24 hour urine sample. It is used to: assess the risk of heart disease and for, anxiety, autism, behavioral disorders, chronic fatigue, fibromyalgia, digestive disorders along with other conditions.

Test Providers Info

There are various places that provide testing for a leaky gut and for related conditions. Below are some examples of the testing you can undergo to pin point your specific problems.

Always visit your doctor if you are suffering from any pain or illness and let your doctor know if you are going to undertake any 'alternative' testing methods.

All the information below was provided by the test providers themselves. There are of course other places that perform various tests. Just be sure to do your research and always consult your doctor.


Biolab is a medical laboratory specialising in nutritional and environmental medicine, measuring minerals, vitamins, fatty acids, toxic metals, pesticides and other environmental chemicals. They have also developed a wide range of methods of assessing the effects of 21st Century lifestyles on our health. Amongst these are two ways of looking at abnormal gut function:

The gut permeability profile (Ł42) uses a substance, polyethylene glycol (PEG 400), which plays no part in human biochemistry, which is ingested as a drink. This solution is made up of known molecular weights, so the quantity of each molecular weight of PEG 400 passed in the urine over the next 6 hours can be used to build a profile of gut absorption (and permeability). PEG 400 which is not absorbed through the gut is excreted in the faeces.

Biolab can also measure the levels of short-chain polypeptides (Ł63) in the blood 1-2 hours after a protein containing meal (your normal main meal of the day). Incomplete digestion of proteins from the meal will result in short-chain polypeptides entering the blood stream. These mimic the action of hormones and cytokines thus disrupting normal biochemical activity.

Biolab can only provide tests if a medical practitioner is willing to receive their reports and assist with the interpretation of the results. They do not offer a service directly to the public. Further details can be found at www.biolab.co.uk.

The Diagnostic Clinic- Dr Rajendra Sharma

The Polyethylene Glycol (PEG) test

The orthodox medical world does not recognise this as a medical condition - yet. There are laboratories in the United States and one here in the United Kingdom that test for this condition using a very simple method. A solution of inert (indigestible and unusable) molecules is drunk and, having emptied the bladder previously, urine is collected for the next six hours. At the end of this time the sample is shaken and a small portion sent to the laboratory. A certain percentage of the small molecules should have passed through the gut wall, into the blood stream and been filtered out by the kidneys into the urine. The larger molecules that were drunk should not have got through and simply pass out with the faeces. The presence of any large molecules, therefore, in the urine indicates the presence of increased intestinal permeability - the Leaky Gut Syndrome.

At this time instructions and collection kits can be sent to an individual. Once the sample is collected it is returned directly to The Diagnostic Clinic and results returned, usually, within 7 days.

The LGS is frequently associated with yeast or fungal infections including Candida. A test called The Gut Fermentation study can give practitioners information regarding the presence of yeast. This simple test involves the patient taking a sugary capsule or drink and an hour later having a blood sample taken to look for alcohols in the bloos. This appears because of the fermentation of sugar by yeasts. This test also gives information about a lack of dietary fibre, possible hypoglycaemia and the presence of good and bad bowel flora.

Food Allergy Testing

Food Allergy Cellular Test is the test of choice regarding food allergy. This looks for a particular inflammatory compound that comes out of White Blood Cells in the presence of an allergic food. Food allergy is a main issue either causative or as an effect of a leaky gut.

Bioresonance Food intolerance testing

Testing for food intolerance can be done using a Bioresonance computer. The Diagnostic Clinic's choice is the QX Quantum CI in the hands of a specialised nutritionist.

BioHit - Stomach acid production assay

Poor digestion can leave large undigested molecules in the small intestine that can damage the inner or epithelial lining of the gut. These larger molecules may also be more likely to trigger an immune response. A new test called BioHit is a blood test that allows us to tell if the stomach lining is producing the correct quantity of acid to ensure breakdown of food.


If a leaky gut is established and symptoms of ill health can be associated with this then treatment is a prerequisite for a return to good health.

Current treatment protocol includes high dose acidophillus (to replenish bowel bacteria and challenge yeast i.e. Candida, infection), herbal antibacterial extracts including berberine from berberis, a special clay powder that releases oxygen into the bowel (most bad bacteria are anaerobic - they don't live in oxygen), herbal extracts known to increase the integrity of mucosal (gut lining) cells and the protein glutamine - a protein essential for bowel membrane integrity.

A diet avoiding fermentable foods - an anti-candida diet is recommended strongly along side the treatments regardless of the evidence for yeast infection as these diets tend to be hypo-allergenic in any case.

Dr Rajendra Sharma is a fully qualified doctor specializing in Integrated Medicine and the Medical Director of The Diagnostic Clinic. Further details can be found at www.thediagnosticclinic.com

IWDL (Individual Well Being Diagnostic Laboratories)

Commonly the causes of a leaky gut include food allergies/ intolerances, intestinal infections (eg candidiasis, parasites), inadequate digestion (which can cause intolerances), chronic stress, excessive intake of coffee, caffeine containing drinks/ sugar/ alcohol, deficiencies of certain key nutrients that repair the intestinal mucosa such as zinc or vitamin A could also worsen this condition.

Treating a leaky gut must always involve treating the cause:

FAC (Food Allergen Cellular) Test [view pdf]

This is a blood test which assesses 233 different foods for any sort of immunological reaction (both allergies and intolerances). It also tests common food additives, flavorings, colorings, seasonings and beverages. Certain foods/ beverages are known to cause damage to the gut wall (alcohol and coffee), while other foods may be eliciting an immune reaction (allergy or intolerance), which causes damage to the gut wall. The cost is Ł245.

Gut Permeability test

This will measure the extent of permeability in the gut, and may be beneficial when monitoring treatment to see how the gut is improving. Cost Ł90.

Comprehensive Stool Analysis with Parasitology [view pdf]

This stool analysis will identify whether there is any bacterial, yeast, parasitic infection, as well as measuring various digestive, absorptive, immunological, inflammatory, and other intestinal health markers. Intestinal pathogens can all cause considerable damage to the intestine wall. Digestive factors such as low stomach acid or pancreatic enzymes can also contribute to allergies or intolerances, which in turn damage the intestinal mucosa. Cost Ł220.

Candida Antibody Profile [view pdf]

This test measures the production of antibodies (IgA and IgG) against Candida, which will help to identify whether there is a yeast overgrowth or not.Cost Ł70.

Gluten Sensitivity Profile

This measures various antibodies to gliadin from gluten, as well as a marker called tissue transglutaminase, which can all help to identify gluten intolerances or untreated coeliac's disease. Costs Ł70.

Comprehensive Adrenal Stress Index [view pdf]

This is a saliva test which measures the circadian rhythm of two important stress hormones, cortisol and DHEA. Chronic stress has well known detrimental effects on digestion, and can directly cause or contribute to a leaky gut. This profile also measures an important marker of immune function, Secretory IgA which is found in gastrointestinal secretions and makes up about 80% of the immune system in the gut. This immunoglobulin forms the first line of defence against any pathogen in the gut which may be causing damage to the gut wall. SIgA levels are frequently depressed with stress. Costs Ł90.

Further details can be found at www.iwdl.net

Test Reviews

There are so many different tests available for digestive disorders and other illnesses that consumers are often baffled by the choice, unsure where to get the test from and ultimately, if the results will be reliable. With that in mind, I have set up a dedicated test review page to give you an insight into the tests that are out there and how effective and useful I have found them to be.

Below are links to the reviews, which are currently in written form but will soon be in video form as well.


Yorktest - Second Step Food Intolerance Test, 113 foodSCAN - Ł265
Genova Diagnostics - Comprehensive Stool Testing with Parasitology - Ł205

Treatments For Leaky Gut

The main way to deal with Leaky Gut Syndrome is through nutrition. It is important to get the body back to optimum health and avoid the foods or toxins that are causing allergic reactions, so that the damaged villi in the intestine have a chance to heal and so that your liver has the time and energy to detoxify your body. There is no wonder drug to cure a leaky gut. Dealing with Leaky Gut Syndrome is about dealing with the causes of the condition as opposed to symptom care.

Below you will find advice for nutrition and supplements that have worked for other people, suggested in various works by nutritional or alternative health care experts, such as Dr Gloria Gilbere, N.D, DA Hom, PhD, Dr Gillian McKeith, Jack Hinze NMD and Liz Lipski, MS, CNN. Please consult your doctor before embarking upon any new dietary regime and please contact a qualified nutritional therapist to tailor your dietary needs. The information provided here is not intended to be an alternative to professional advice given directly by a qualified medical practitioner, as each individual has different requirements.

What You Should Avoid


What Foods Can Help?

Buy organic predominantly raw foods when you can, especially fruit and vegetables which are richer in nutrients as they are not grown in mineral deficient artificial fertilizers and then sprayed with pesticides, herbicides or fungicides. You can bottle some great nourishing raw food recipes at Kristen's Raw.

Eat lots of vegetables. They contain antioxidants (these bind themselves to free radicals altering them to prevent cellular damage) that are said to fight free radicals (highly unstable, reactive atoms that can damage cells and have been linked to the advance of illnesses such as, cancer and cardiovascular disease) such as beta carotene, vitamins A and C, minerals, enzymes.

The amount of Omega 3 fatty acids and Omega 6 fatty acids you consume needs to be balanced as evidence has suggested that an imbalance may be a contributor to certain illnesses.

Omega 6 fatty acids can be found in the oils of seeds and grains. Sunflower, safflower, wheat germ, sesame, pumpkin and corn oil are rich in linoleic acid as is evening primrose and borage oil, which also contains Gamma Linoleic Acids (GLA). Vegetables, fruits, grains, seeds and nuts are also a source of linoleic acid. Flaxseed oil is a rich source of Omega 3 acids as is fish oil, however flaxseed oil is much richer source of alpha-linolenic acid than fish. Walnut oil are also rich sources of Omega 3 acids. Green leafy vegetables, pumpkin seeds, mustard seeds, grains, soya beans and spirulina also provide Omega 3 acids.

[1] Johnston IM, Johnston JR, 1990, Flaxseed (Linseed) Oil and the power of Omega 3, Keats Publishing.
[2] Dennis L, Gregory T, http://www.medicinenet.com/script/main/art.asp?articlekey=23820&page#tocl..

Supplements & Herbs

Taking digestive enzymes can reduce gas and bloating.

Taking HCL (Hydrochloric acid) supplements and natural antacids can aid digestion.

Take Aloe Vera Juice daily as it is said to have anti -inflammatory properties along with a natural laxative effect to help clear out the bowels.

Take Milk Thistle, which is said to protect the liver and kidneys.

N.B. My favorite supplement store is Iherb where I buy almost everything I need because it's inexpensive, has a better range of products than anyone else, shipping is super-speedy, free for U.S. orders over $60 and cheap for international orders (I get my orders in two days shipped to the UK!) If you have never shopped at Iherb before and you use the code DAW513 at the checkout in the promo box you will receive a $5 discount off your first order. N101 Nutrition Health and Support are also very good and inexpensive compared to other online vitamin stores. Some of their products are even cheaper than Iherb! You will find links below to some very good supplements.


Do not embark upon any supplement regime without consulting a medical doctor and/or a qualified nutritionist. The information written here is intended only as general guidance and is not a substitute for a healthy diet or professional medical advice.

Barton RG, 1997, "Immune-enhancing enteral formulas: are they beneficial in critically ill patients?" Nutrition in Clinical Practice (12) pp 51-62.

Other Tips For Leaky Gut

Chew food properly so that your digestive system has an easier time breaking down foods.

Try a food rotation plan (under the supervision of a qualified nutritionist) to identify the culprits causing allergic reactions.

Always carry food with you so that wherever you go, you will always have a healthy snack to hand.

·  Reduce your intake of medications (if you can) that may be contributing to Leaky Gut Syndrome (please note, you should always check with your doctor before altering your medication dosage, do not go against your doctors advice if you are on medication for a certain condition).

·  Use natural, organic cleaning products, bath products and cosmetics. Many normal products on the shelves contain dangerous ingredients, for instance Sodium Lauryl Sulphate used in many bath and shower products first had it's outing as an industrial degreasant and garage floor cleaner. Bearing in mind that our body is said to absorb 60% of the creams, lotions and potions we rub into it on a daily basis we have to be careful what products we use.

Like any detergent Sodium Lauryl Sulphate attacks grease to help keep surfaces clean but the skin secretes oil to keep itself protected, supple and waterproof. Sodium Lauryl Sulphate strips away the skins oil causing dryness and in some cases much worse. A study referenced in the Wall Street Journal (November 1, 1988) linked SLS to cataracts and nitrate absorption (nitrates are carcinogens-or cancer causing substances). Many products also contain alcohol, parabens and other chemicals, which can cause allergic reactions or worse.

·  Eat small, frequent meals.

·  Only eat when you are hungry.

·  Take up something that helps you deal with stress and aids relaxation: such as meditation, Reiki, Qi Gong, Yoga. Make sure that any exercise you do is gentle.

·  Dry skin brushing helps to cleanse the lymphatic system. Dr Gilbere says to brush before taking a bath or shower, always brushing towards the centre of your body with one clean sweep for every part of your body.

·  Try Colonic Hydrotherapy, which dislodges putrified waste from the colon walls.

·  Coffee enemas are said to cleanse the liver and have been used as a detoxification method for many years. The Gerson Therapy uses coffee enemas several times a day on a daily basis to rid the body of toxins. Please contact a professional Gerson practitioner or other health practitioner who knows how the enemas should be administered before attempting to do it yourself.

·  Get plenty of sleep. It has been said that most adults require between 8-9 hours sleep a night and many people get less than this. It has been demonstrated that lack of sleep can result in: a drop in body temperature, a weakening of the immune system (low white blood cell count) and a drop in the production of growth hormone. [1] Also , even if you don't feel tired try to go to bed at least before 11pm.

Books for your Health

Below are various books that are useful for those suffering from illnesses such as chronic fatigue syndrome, fibromyalgia, digestive disorders, heart problems and numerous others. I have personally found these books to be useful. The books I most highly recommend are From Fatigued to Fantastic by Dr. Jacob Teitelbaum M.D. and for the science behind multisystem illnesses, Explaining "Unexplained Illnesses," by Martin L. Pall of Washington State University.

From Fatigued to Fantastic Explaining 'Unexplained Illnesses': Disease Paradigm for Chronic Fatigue Syndrome, Multiple Chemical Sensitivity, Fibromyalgia, Post-Traumatic Stress Disorder, and Gulf War Syndrome

From Fatigued to Fantastic
by Jacob Teitelbaum $10.85

Explaining 'Unexplained Illnesses': Disease...
by Martin L. Pall $88.65

Pain Free 1-2-3: A Proven Program for Elimi...
by Jacob Teitelbaum $12.21

Food is Better Medicine Than Drugs: Your Pr...
by Patrick Holford $21.91

Food is Better Medicine Than Drugs: Your Prescription for Drug-free Health The Complete Book of Raw Food, Second Edition: Healthy, Delicious Vegetarian Cuisine Made with Living Foods * Includes More Than 400 Recipes from the World's Top Raw Food Chefs Raw: The Uncook Book: New Vegetarian Food for Life

The Complete Book of Raw Food, Second Editi...
$19.80Raw: The Uncook Book: New Vegetarian Food f...
by Juliano Brotman $25.08
You are What You Eat Cookbook Dr. Gillian McKeith's Living Food for Health: 12 Natural Superfoods to Transform Your Health The New Optimum Nutrition Bible 
You are What You Eat Cookbook by Gillian McKeith
Dr. Gillian McKeith's Living Food for Healt...
by Gillian McKeith  $12.95

The New Optimum Nutrition Bible by Patrick Holford

Do not embark upon any supplement regime without consulting a medical doctor and/or a qualified nutritionist. The information written here is intended only as general guidance and is not a substitute for a healthy diet or professional medical advice.

Barton RG, 1997, "Immune-enhancing enteral formulas: are they beneficial in critically ill patients?" Nutrition in Clinical Practice (12) pp 51-62.


Below you can find links to: diagnostic service providers, clinics, health care consultants, nutritional therapists, websites offering information about conditions that have been linked with Leaky Gut Syndrome, and other useful links. For practitioners and diagnostic service providers, if you feel your services are relevant I will consider a link exchange.

Testing Services, Treatments and Consultants

- integrated therapeutic and diagnostic centre with highly qualified doctors offering expertise in nutrition and alternative medicine, supported by a team of nurses, practitioners, patient assistants and the latest technology. Click here to read about the tests offered at the Diagnostic clinic for Leaky Gut Syndrome and related digestive disorders.

- a medical referral laboratory specialising in nutritional and environmental medicine, measuring minerals, vitamins, fatty acids, toxic metals, pesticides and other environmental chemicals. Click here to read about the tests offered at Biolab for Leaky Gut Syndrome and related disorders.

www.iwdl.net -
offering advanced diagnostic services and nutritional counselling. Click here to read about the tests offered by IWDL for Leaky Gut Syndrome and related disorders.

www.cambridge-nutritional.com -
offering diagnostic and screening tests.

www.puremedicine.com -based in Harley Street, offering healthcare consultations and advice. Pure Medicine offers a team of highly qualified therapists, specialising in specific areas of health.

Nutritional Therapy

www.bant.org.uk (British Association for Nutritional Therapy) The Professional Body for Nutritional Therapists have a directory of BANT qualified nutritional therapists in the UK.

www.ion.ac.uk (Institute of Optimum Nutrition) an independent charity, established for the study, research and practice of nutrition have a directory of ION qualified nutritional therapists in the UK.

www.patrickholford.com - Patrick Holford, nutritionist, founder of the Institute of Optimum Nutrition and author of many books on health, with the latest being, 'Food Is Better Medicine Than Drugs.' Patrick's website has an online health assessment and many resources for health and well-being.

www.drgloriagilbere.com - Gloria Gilbere, ND, DAHom, PhD is a health practitioner based in the US who has suffered from and overcome Leaky Gut Syndrome herself. Gloria offers consultations via telephone to people around the world.

www.innovativehealing.com - Liz Lipski, PhD, CCN is a nutritional therapist based in the US. Click here to read a chapter from Liz's book Digestive Wellness, about Leaky Gut Syndrome.

Laurel Garwin - a nutritional therapist and coach practicing in San Francisco can be contacted at lgarwin@pacbell.net. Click here to read an article by Laurel about Leaky Gut Syndrome.

www.liverdoctor.com- Sandra Cabot MD and Margaret Jasinska ND specialise in helping people with weight problems, liver dysfunction and hormonal imbalances. They are based in the US. Click here to read an excerpt from their book The Ultimate Detox.

Some Conditions Linked to Leaky Gut Syndrome

www.mssociety.org.uk (Multiple Sclerosis Society)
www.nas.org.uk (National Autistic Society)
http://osiris.sunderland.ac.uk/autism/ (Autism Research Unit, University of Sunderland)
www.nacc.org.uk (National Association for Colitis and Crohn's Disease)
www.ibsnetwork.org.uk (Irritable Bowel Syndrome Network)
www.candida-society.org.uk (National Candida Society)
www.cftrust.org.uk (Cystic Fibrosis Trust)

Organic and Natural Foods and Products

www.mariposa-alternative-bodycare.co.uk offer natural and organic skincare, plus, baby care, feminine hygiene, fairtrade organic cotton wool and more. Order securely online or call 01273 242 925.

www.everybodyorganic.co.uk offer fresh and organic fruit and vegetables delivered to your door every week.

www.hedgerowherbals.com offer herb and flower hand made soaps along with skin creams, candles, bath products, herbal oils and compounds and syrups to aid various conditions.

www.ecospaints.com offer odorless organic paints free from solvents, animal products, heavy metals, formaldehyde and vinyl chloride.

Mind Body and Soul

www.thehealingco.com - Reiki treatments for all conditions and certified Reiki courses in the Usui System of Natural Healing to allow you to heal yourself and others physically, emotionally and spiritually. The courses are held at myhotel Chelsea and Enfield North London.

www.activ-energy.com - Reiki treatments to work on all conditions, Reiki courses to all levels, stress management courses and workshops and indulgence days offering a range of complementary therapies. We also offer Reiki treatments for schools, to help children suffering from behavioural disorders such as Attention Deficit Hyperactivity Disorder (ADHD).

www.qpinnovations.com - psychometric testing, life coaching and team building.

www.dawnmellowship.com - Journalist, Reiki teacher and author of spiritual and self-help books. Dawn's first book Passage to Freedom is out on 22nd February 2008, published by O Books and her second book, You Can Only Achieve What Is Possible an anti self-help, self-help guide is out on 25th April 2008, published by O Books.

http://spirituality.thehealingco.com - Spirituality blog, discussing anything of a spiritual nature, including religion, books, reviews, Reiki and more.

Other Links

www.jrsm.org (The Journal of The Royal Society of Medicine)

www.lp299v.co.uk Lp299v A highly informative, research based website dedicated entirely to the probiotic Lactobacillus plantarum 299v (Lp299v) and its usefulness for Irritable Bowel Syndrome (IBS).

www.questhealthlibrary.com Quest Health Library
A comprehensive site providing referenced information on vitamins, minerals, herbs, health supplements and a variety of health conditions. Updated on a regular basis, the site provides information on the latest findings in nutritional science, and is ideal for health practitioners, students and journalists.

   Dr Rajendra Sharma MB, B.Ch, BAO, MF Hom, MRCH

Dr Sharma is the former Medical Director of Britain's largest alternative Medical Centre the Hale Clinic and is now the Medical Director of The Diagnostic Clinic, an Integrated Diagnostic and Therapeutic Centre. Dr Sharma is the founder of the International Holistic Health Association and has worked with top specialists in numerous fields. He has made several radio and TV appearances and contributes to various publications.

Dr Sharma has also written a family medical book entitled The Family Encyclopedia of Health providing descriptions of complementary and orthodox treatments for most illnesses.

On this page you will find links to articles written by Dr Sharma and, answers to various questions posted by readers of this website.

Contact The Diagnostic Clinic for a consultation with Dr Rajendra Sharma, diagnostic services or for further information at www.thediagnosticclinic.com.


Leaky Gut Syndrome

Q & As - Ask Dr Rajendra Sharma


We have 3 daughters (5, 4, and 10 months). About 6 months ago all of their skin looked really bad. This was also when our youngest had her "well visit" which included a heavy dose of vaccinations. She had some reactions to it, which is when I began to do some research to link food allergies and immunizations.

My older daughters have some severe food allergies/eczema, and asthma. Through much prayer I really believe that the Lord guided me to many different sites that showed me the ingredients that are in vaccinations and it really scared me. I also stumbled (very briefly) upon a website that suggested that leaky gut could come about because of vaccinations. I, at this point, didn't know very much about leaky gut, and put it on the back burner until yesterday when I discovered your site.

I was shocked at all of the information that I found out. My oldest is doing much better (although I believe that she may have a more mild case of leaky gut) but my middle child is doing rather poorly (so I am naturally more worried about her than the other two). I am scheduled to get some testing done (urine/stool/blood analysis, as well as some hair tests to test for toxic metals) to rule out some problems and hopefully diagnose her a bit better. I really don't know what she has. Her skin looks absolutely horrible. She has eczema on all of her extremities and she complains that her belly hurts often. She eats extremely healthy foods, probably than most of her counterparts, but I don't feel she is absorbing them as she should.

My baby is doing fine since I eliminated dairy and eggs from my diet (she is still breastfeeding--almost exclusively). A doctor (and some experienced moms) told me that breastfeeding exclusively for a year would help to eliminate the chance of developing food allergies so that her immune system can develop properly. This seems like an uphill battle for me. This issue has caused me to rely on my faith and not on my own abilities, which are truly insignificant compared to what God can do. I guess my question is: what is the most important test that can be done to give the best indication that my daughter has a leaky gut? I'd like to have this one done first so that we can get the ball rolling with her diet and such."


"Your three daughters aged five, four and ten months certainly need to be under the care of an Integrated Physician and to find somebody locally your best bet would be to contact The Faculty of Homoeopathy on 0870 444 3945, who can give you a list of doctors who are also homoeopaths. You could specifically contact Dr David Freed in Salford or Dr John Mansfield at the Burghwood Clinic in Surrey who are Integrated Physicians and specialize in allergies. Their details are as follows: The Burghwood Clinic Tel: 01737 361177.

Your specific question concerning leaky gut would be a PEG or Mannitol urine test which requires a six-hour collection which is possible on your five and four-year-old. The kit can be sent out to you by The Diagnostic Clinic with instructions and the results returned with a commentary and some basic advice. Your ten-month-old baby cannot be tested this way and there is no established method for individuals from whom a urine sample cannot be collected.

However, ongoing research into Live Blood Analysis suggests that the finding of large numbers of food particles in the bloodstream looked at under high-powered microscopy may be an indicator of the leaky gut. This would require your baby having a tiny pinprick of blood placed on a slide at a centre that performs Live Blood Analysis. Again, depending on where you are in the country you would need to choose by looking on the Internet as there is no particular association from which to obtain lists of practitioners/doctors utilizing this test.

Again, The Diagnostic Clinic in Central London can offer you the service and a booking can be made on 020 7009 4650. If your baby is doing better since you eliminated dairy and eggs from your diet whilst breastfeeding then I dare say it has crossed your mind to eliminate these as best you can from your other children's diet. Specific practitioners can provide anti-fermentation diets that can be used in leaky guts where yeast or bad bacteria are considered to be contributory. Shea ointment is an extract from an African plant that seems to be useful in severe eczema and, to date, has not been reported as having any major side-effects but it is always important to get the blessing of your GP or dermatologist before trying anything and always stop if a problem appears to be getting worse......
Dr Rajendra Sharma."

Dr Gloria Gilbčre ND, DA Hom, Ph D

Dr Gilbčre is a traditional naturopath, homeopath and doctor of natural health. As Director of Global Integrated Health and EcoErgonomics Environmental Health, she consults with clients, researchers and physicians around the world regarding various modalities of natural and integrative health. Dr Gilbčre teaches, lectures and consults worldwide as well as writing articles for numerous publications.

Dr Gilbčre has written more than 400 articles and several books.

Dr Gilbčre recovered from Leaky Gut Syndrome and related multiple allergic responses herself and knows how debilitating the condition can be. Click here for Dr Gilbčre's bio, including information about her published books. Click here for information about her educational seminar cruises.

To contact Dr Gilbčre directly for a consultation please email info@drgloriagilbere.com and for further information you can find her website at www.drgloriagilbere.com.


Leaky Gut Syndrome: The Intestinal Terrorist [pdf version]
Skin & Intestinal Disorders: Different Symptoms, Same Causes [pdf version]
Inflammation: A Serious Warning Light
Summer: Bathing, Picnics and Bacteria [pdf version]
The Hidden Cause of Many Inflammatory Disorders [pdf version]

Q & A - Ask Dr Gilbčre


"I have been incapacitated for a long time with no answers from my doctor or anybody else - When I describe how I feel I can see the glaze coming over the eyes of my doctor - and I changed from a male to a female hoping I would get some answers.

The one thing I have been diagnosed with is Multiple Chemical Sensitivities (and a nickel allergy).The consultant I saw told me I had MCS and then said there was nothing they could do for me. After coming online recently i found Allergy UK which had some factsheets on the subject

After another particularly awful night (no sleep) with the symptoms of goodness knows what I looked on the information again that allergy UK had sent me and saw about leaky gut and from there I found this website and joined!

I know we should not self diagnose but when the professionals don't know what to do you have to do something for yourself. I have been on so many exclusion diets I am at a loss .There's something wrong with me and I find it amazing in this day and age that that a doctor has no clue I seem to have multiple intolerances to different foods and can use only Simple soap and shampoo.

My one question this time round is have any of you had tests for leaky gut and would you recommend the test (and which one)? Is your own GP able to carry these out?"


"Thank you for your question. The best test to indicate the presence of leaky gut (intestinal permeability) is performed by a lab called "Great Smokies" and is based in North Carolina. The test must be ordered by a health professional.

However, unfortunately speaking from first-hand experience, you probably don't need a test to prove it especially if you have multiple allergies as you described. The best solution is to start by reducing the overall toxic load of the body through changing your immediate environment to that of as much as possible non-toxic substances. Then you must proceed to clean out the large intestine with professional colon cleanse products, colonic irrigation (if possible) and then supplementing your diet with a functional food (formerly known as medical food) that contains ingredients like L-glutamine to assist in repairing the gut lining.

The best information would be found in the first two books written by Dr. Gilbčre called, "I was Poisoned by my body" and "Invisible Illnesses". They are available online at major booksellers or directly from her office by email at drgilberesoffice@hotmail.com. Several articles will also be posted on this site within the next month to assist those with these symptoms. Being a recovered victim of these life-altering disorders, know that there is help...Dr. Gilbere"


"I was hoping you if you would answer one question; In your opinion could "leaky gut" result to infertility? I have had chronic fatigue for almost 7 years and I have been trying to fall pregnant for 4 years without any success. Recently my doctor diagnosed me with "leaky gut" but was very doubtful it was causing infertility. I am iron deficient but my period has always been regular."


"I can only speak from personal observation and experience, not from the conventional medical viewpoint.

It is my belief that infertility can be caused by leaky gut when we consider that the entire immune functions are compromised with toxic matter being expelled throughout the body. In addition, most leaky gut victims have a challenge with excessive yeast (Candida albicans), which can play havoc with the reproductive organs and causes not only intestinal inflammation but also poisons us with the by-products of the yeast.

I personally had 6 miscarriages in my 20's and both my grown sons were adopted as newborns. My problem was the opposite - I conceived easily but couldn't carry to term (most only to the 4-7th month). In retrospect, and after becoming a doctor specializing in digestive disorders, I realize I had chronic yeast infections that were always treated with antibiotics - further causing more yeast and creating a vicious cycle. Most young woman I've consulted with that have problems with conceiving would benefit from the following:

1. Make sure you eliminate daily one to three times.
2. Perform a good professional-grade fiber colon cleanse to "brush" colonic plaque away from the walls, allowing you to then be able to heal the leaky gut. Be sure you do not get constipated or having difficulty eliminating, if so, use an herbal stool softener without herbs known to be habit forming such as Cascara Sagrada or Senna (these herbs are very aggressive and should only be used, in my opinion, for cases of acute constipation).
3. After you've reduced your intestinal toxic load with a fiber cleanse daily for about 90 days, then you can do an herbal candida yeast cleanse, follow the protocol which is usually 2 weeks of 2 capsules twice a day, rest one week and repeat until you've done 6 weeks of candida yeast cleanse.

Meanwhile, continue to take a good fiber colon cleanse so that you don't kill organisms and have them stay within the intestines. Drink plenty of water, at least half your body weight in ounces daily (example: a person weighing 150 lbs. would need 75 oz. of water)
4. Be sure you get a good Vitamin "B" complex that contains 100 mg. of each of the B's including 400 mcg. of folic acid.
5. Be sure you take at least 2,000 mg. of buffered Vitamin "C" and adjust according to your weight and bowel tolerance.
6. Now you can start a protocol for helping the body to repair the intestinal lining by taking supplements called Functional Food that contains a vegetable-based protein as well as amino acids known to repair intestinal mucosa.

I pray the stork will be visiting you soon....parenting is the hardest job on earth yet the most rewarding...and then we are rewarded for our parenting with the "frosting on the cake"... grandchildren (I presently am blessed with two)..... Dr. G

P.S. It would be helpful for you to read my book "Invisible Illnesses" and also to consider colon hydrotherapy by a professional."



The content of this website is for informational purposes only and is not intended to take the place of professional, medical advice or to treat, prevent, diagnose or cure any disease. Always consult your doctor about any queries you may have regarding a medical condition and prior to undertaking any dietary, fitness or other health regime.